Type 1 Diabetes TrialNet

TrialNet is a network of researchers who are dedicated to learning how type 1 diabetes (T1D) can be prevented in relatives of people with the disease. Relatives have a higher chance of developing the disease when compared to the general population. 

TrialNet is working to identify type 1 diabetes at its earliest stages and find ways to delay or prevent the condition in individuals at risk.

TrialNet screening looks for five diabetes-related autoantibodies that signal an increased risk of T1D. This screening test can detect these autoantibodies up to 10 years before diagnosis.

Type 1 diabetes can now be most accurately understood as a disease that progresses in three distinct stages:

Stage one is the start of type 1 diabetes. This occurs when individuals test positive for two or more diabetes-related autoantibodies. The immune system has already begun attacking the insulin-producing beta cells, although there are no symptoms and blood sugar remains normal.

Stage two, like stage one, includes individuals who have two or more diabetes-related autoantibodies, but now the blood sugar levels have become abnormal due to an increased loss of beta cells. However, there are still no symptoms. For both stages one and two, lifetime risk of developing type 1 diabetes approaches 100%.

By stage three, clinical diagnosis has typically taken place because there is significant loss of beta cells and individuals generally show the common symptoms of type 1 diabetes. This includes frequent urination, excessive thirst, weight loss, and fatigue. 

You can find out if you and your family are at risk for type 1 diabetes.

Screening is the first step on the pathway to prevention. You can be screened by TrialNet if you are:

2.5 to 45 years old AND have a parent, child, brother, or sister with type 1 diabetes


2.5 to 20 years old AND have a niece, nephew, aunt, uncle, grandparent, half-brother, half-sister, or cousin with type 1 diabetes 

How to get screened:

  •  Screening test kits are available. We will send you a test kit to complete from the comfort of your own home or, if you prefer, there is also an option to bring the test kit to a local lab for a blood draw.
  • We also offer screening by appointment. TrialNet has more than 200 study locations around the world. To find the one closest to you, call (toll-free) 1.866.699.1899 or visit trialnet.org
  •  Screening is offered at no cost to you, with results available in about six weeks

It is important to know:

  • Knowing your risk for diabetes gives you important information about your long-term health. It also lets you know if you are eligible to take part in a prevention study.

Prevention studies

If you are identified as being at risk for type 1 diabetes, there are research studies testing ways to delay or prevent it. TrialNet offers prevention studies for relatives of people with type 1 diabetes, depending on their risk level. The study team will discuss these options with you. If you are not eligible to join a current prevention study, you can still be a part of TrialNet research. Even if you are not eligible to join a prevention study when you are first screened, you can continue to be closely monitored for the earliest signs of type 1 diabetes.

For more information or if you would like to get screened, please contact:

Toll-free number: 1.866.699.1899

Email: [email protected]

For more information, visit the Type 1 Diabetes TrialNet site at DiabetesTrialNet.org.

Lets turn type one into type none