JDRF CCTN Clinical Trials

A Safety, Tolerability, and Efficacy Study of VC-01™ Combination Product in Subjects With Type I Diabetes Mellitus  {Trial ID: NCT02239354}

Condition:Type 1 Diabetes Mellitus, Ages 18 to 55

Intervention: 
Device: VC-01™ Combination Product

Recruiting:
University of Alberta Hospital
Edmonton, Alberta, Canada,
T6G 2B7

Principal Investigator:
Dr. James Shapiro

Contact:
Andrew Malcolm
780.407.7330 or
780.407.1480
amalcolm@ualberta.ca

Pilot Clinical Trial of Ustekinumab in Patients With New-onset T1D (UST1D) {Trial ID: NCT02117765}

Condition:
Type 1 diabetes, Ages 18 to 35

Intervention:
Drug:Ustekinumab

Recruiting:
BC Diabetes
400 - 210 West Broadway,
Vancouver, BC V5Z 1M9

Principal Investigator:
Tom Elliott, MBBS, FRCPC

Contact:
Marla Inducil, BSc Pharm,
MD, CCRP   
604.628.7253  
minducil@bcdiabetes.ca 

A Randomized Controlled Trial to Evaluate the Efficacy and Safety of a Gluten-Free Diet in Patients with Asymptomatic Celiac Disease and Type 1 Diabetes:Celiac disease and Diabetes – Dietary Intervention and Evaluation Trial (CD-DIET) {Trial ID: NCT01566110}

Condition:
Type 1 diabetes, age 8 to 40

Intervention:
Screening for asymptomatic Celiac disease; assignment to a gluten-free diet compared to usual gluten-containing diet.

Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial (CONCEPTT) {Trial ID: NCT01788527}

Condition:
Type 1 diabetes, female, age 18 to 40; pregnant with singleton fetus (gestational age at 13 weeks six days or less) OR planning to conceive and interested in optimizing glycemic control before conception

Intervention:
Usage of Real-Time Continuous Glucose Monitoring (RT-CGM) along with standard intensive insulin regimen, compared to continuation on standard intensive insulin regimen without RT-CGM

Timing of Initiation of Continuous Glucose Monitoring in Established Pediatric Diabetes Trial (CGM TIME Trial) {Trial ID: NCT01295788}

Condition:
Type 1 diabetes, age 5 to 18

Intervention:
Timing of initiation of continuous glucose monitoring (CGM) and pump therapy

Structured Transition from Pediatric Care to Adult Care in Type 1 Diabetes Trial (Transition Trial) {Trial ID: NCT01351857}

Condition:
Type 1 diabetes, age 17-20

Intervention:
Structured 18-month transition program from pediatric to adult care, compared to standard diabetes care

Reducing with Metformin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL) {Trial ID: NCT01483560}

Condition:
Type 1 diabetes, age 40 and older

Intervention:
Reducing with metformin microvascular outcomes and vascular complications

Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) {Trial ID: NCT01581476}

Condition:
Type 1 diabetes, age 10 to 16

Intervention:
Screening for risk of developing complications from diabetes and early intervention with currently approved medications

Artificial Pancreas Standards and Technical Platform Project

Feasibility Assessment of Prototype Nocturnal Hypoglycemia Reduction System {Trial ID: NCT01591681}

Condition:
Type 1 diabetes, age 15 and older, on insulin pump therapy

Intervention:
Algorithms to predict hypoglycemic episodes and suspension of insulin delivery to prevent nocturnal hypoglycemia

Pilot Study of a Semi-Structured Computerized Overnight Basal Rate Assessment Protocol to Reduce Nocturnal Hypoglycemia {Trial ID: NCT01823341}

Condition:
Type 1 diabetes, age 18 and older, on insulin pump therapy

Intervention:
Three-week usage of a computerized overnight basal rate assessment tool that uses readings from a continuous glucose monitor.

Healthy Moms, Healthy Babies: A Strategy to Improve the Care and Outcome of Diabetes in Pregnancy in On-Reserve First Nations Women {Trial ID: NCT01578460}

Condition:
Diabetes, female, First Nations descent, age 18 and over, pregnant (gestational age 36 weeks or less)