JDRF CCTN Clinical Trials

 


Please click on the trial title to display additional information, including details on eligibility to participate in each trial.

The following clinical trials are active and currently recruiting participants 

A Safety, Tolerability, and Efficacy Study of VC-01™ Combination Product in Subjects With Type I Diabetes Mellitus  {Trial ID: NCT02239354}

Condition:Type 1 Diabetes Mellitus, Ages 18 to 55

Intervention: 
Device: VC-01™ Combination Product

Recruiting:
University of Alberta Hospital
Edmonton, Alberta, Canada,
T6G 2B7

Principal Investigator:
Dr. James Shapiro

Contact:
Andrew Malcolm
780.407.7330 or
780.407.1480
amalcolm@ualberta.ca


Pilot Clinical Trial of Ustekinumab in Patients With New-onset T1D (UST1D) {Trial ID: NCT02117765}

Condition:
Type 1 diabetes, Ages 18 to 35

Intervention:
Drug:Ustekinumab

Recruiting:
BC Diabetes
400 - 210 West Broadway,
Vancouver, BC V5Z 1M9

Principal Investigator:
Tom Elliott, MBBS, FRCPC

Contact:
Marla Inducil, BSc Pharm,
MD, CCRP   
604.628.7253  
minducil@bcdiabetes.ca 


Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial (CONCEPTT) {Trial ID: NCT01788527}

Condition:
Type 1 diabetes, female, age 18 to 40; pregnant with singleton fetus (gestational age at 13 weeks six days or less) OR planning to conceive and interested in optimizing glycemic control before conception

Intervention:
Usage of Real-Time Continuous Glucose Monitoring (RT-CGM) along with standard intensive insulin regimen, compared to continuation on standard intensive insulin regimen without RT-CGM


A Randomized Controlled Trial to Evaluate the Efficacy and Safety of a Gluten-Free Diet in Patients with Asymptomatic Celiac Disease and Type 1 Diabetes:Celiac disease and Diabetes – Dietary Intervention and Evaluation Trial (CD-DIET) {Trial ID: NCT01566110}

Condition:
Type 1 diabetes, age 8 to 40

Intervention:
Screening for asymptomatic Celiac disease; assignment to a gluten-free diet compared to usual gluten-containing diet.


The following clinical trials will open for patient participation in 2015


None at this time.


The following clinical studies are active but no longer currently recruiting participants

Timing of Initiation of Continuous Glucose Monitoring in Established Pediatric Diabetes Trial (CGM TIME Trial) {Trial ID: NCT01295788}

Condition:
Type 1 diabetes, age 5 to 18

Intervention:
Timing of initiation of continuous glucose monitoring (CGM) and pump therapy


Structured Transition from Pediatric Care to Adult Care in Type 1 Diabetes Trial (Transition Trial) {Trial ID: NCT01351857}

Condition:
Type 1 diabetes, age 17-20

Intervention:
Structured 18-month transition program from pediatric to adult care, compared to standard diabetes care


Reducing with Metformin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL) {Trial ID: NCT01483560}

Condition:
Type 1 diabetes, age 40 and older

Intervention:
Reducing with metformin microvascular outcomes and vascular complications


Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) {Trial ID: NCT01581476}

Condition:
Type 1 diabetes, age 10 to 16

Intervention:
Screening for risk of developing complications from diabetes and early intervention with currently approved medications


The following pre-clinical and/or technology development studies are active.  

Artificial Pancreas Standards and Technical Platform Project


The following CCTN-funded studies have been completed
 

Feasibility Assessment of Prototype Nocturnal Hypoglycemia Reduction System {Trial ID: NCT01591681}

Condition:
Type 1 diabetes, age 15 and older, on insulin pump therapy

Intervention:
Algorithms to predict hypoglycemic episodes and suspension of insulin delivery to prevent nocturnal hypoglycemia


Pilot Study of a Semi-Structured Computerized Overnight Basal Rate Assessment Protocol to Reduce Nocturnal Hypoglycemia {Trial ID: NCT01823341}

Condition:
Type 1 diabetes, age 18 and older, on insulin pump therapy

Intervention:
Three-week usage of a computerized overnight basal rate assessment tool that uses readings from a continuous glucose monitor.


Healthy Moms, Healthy Babies: A Strategy to Improve the Care and Outcome of Diabetes in Pregnancy in On-Reserve First Nations Women {Trial ID: NCT01578460}

Condition:
Diabetes, female, First Nations descent, age 18 and over, pregnant (gestational age 36 weeks or less)


Find More Clinical Trials
 

Below is a list of other organizations and websites that typically have listings of clinical trials for T1D:

Clinical Research Networks

Clinical Trial Listing Sites

Research Proposals to JDRF CCTN

JDRF CCTN clinical trials and research and development projects are derived from two primary sources:

Investigator-initiated Proposals

Proposals: Although proposals are welcomed by JDRF CCTN, JDRF CCTN cannot provide assurance of available funding at the time of receipt. Applicants should note that proposals submitted to JDRF CCTN may be redirected through regular JDRF funding channels. Therefore, investigators wishing to submit proposals are encouraged to contact JDRF CCTN for guidance prior to preparation and submission, as well as consult JDRF International research funding program guidelines.

For more information or questions about investigator-initiated research proposals with JDRF CCTN, please contact Olivia Lou, Program Officer at olou@jdrf.ca or Robert Goldstein, Senior Advisor at gold@jdrf.ca.

Industry Partnership Proposals

JDRF CCTN is interested in hearing from Canadian or international companies regarding collaborative research partnerships that would enhance JDRF CCTN's ability to accelerate the development and/or commercialization of treatments and technologies for the management and cure of type 1 diabetes. JDRF CCTN offers a flexible partnership model designed to maximize development opportunities within JDRF CCTN framework. Interested individuals are asked to contact Robert Goldstein, Senior Advisor at gold@jdrf.ca.

Lets turn type one into type none